I recently helped someone who was having very odd problems with CSS rendering in Firefox and Dreamweaver, and nothing worked (reinstalling apps, disabling extensions, safe boot, etc.) until we created a new user account.
What finally got things working back in the primary user account was to do a deep cache cleaning of all system, user, and application caches and rebooting (I used Cocktail, though I'm sure others will use other similar maintenance utilities; see this Macworld overview of maintenance tasks and utilties). So doing this kind of cleaning might be worth a try if you haven't done so yet.
If I were a betting man, my money would be on an obscure corrupt Rosetta cache file (especially if Accordance is the only non Intel-native app you're running)!
Thanks for this tip as well. I had the exact same thought this afternoon, so as soon as I got home I ran Onyx and all its options....unfortunately, did not change anything! I'd hate to have to run Accordance off another user account! I have not had any trouble with old MS office which is still non-Intel (outside the normal MS office problems!). I have not tried a safe boot yet, perhaps I'll give that a go.