Interesting topic. When we moved to Acc-11, I decided to simplify things by going to a unicode font for everything. But there were characteristics I really wanted to maximize readability.
First, I find that shorter, wider fonts work best for me. Tall narrow ones are harder to read.
Second, I wanted to use a font that distinguished between an l, an I, and a 1 (a lower case l, upper case I, and the number 1).
Third, I wanted one that didn't have a bold that screamed bold (like Times New Roman does). The font also had to have an italic – needed for texts, tools, and User Notes – but not an italic that looked like it had been washed in really hot water (like Baskerville's italic – sorry, Graham).
Finally, Greek, Hebrew and English fonts had to be in balance so that all were readable at the same size (point?). I settled on Gentium Basic @16 with 20 leading for texts & 27 leading for tools. Here's a sample workspace. User Notes Gentium Basic @14; SBL Greek.
I would greatly appreciate suggestions for other unicode Greek and Hebrew. I prefer the look of Helena. SBL Greek is too narrow for my taste, and I don't like the tilt.
Those of you with younger eyes may think I've gone all OCD over fonts. Just wait until you get past your 60th birthday.
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